Antibiotics: Right Choice for Fighting Bacterial Infeсtions Successfully

Amoxil Online

Amoxil is an antibiotic from the group of semisynthetic amino-penicillins with a broad spectrum of antibacterial action. The drug provides a bactericidal effect and is active against many pathogenic germs.

Amoxil proves effective in the treatment of infectious diseases, caused by:

Gram-Positive Bacteria

  • Streptococcus spp.
  • Enterococcus faecalis
  • Streptococcus pyogenes
  • Streptococcus pneumoniae

Gram-Negative Bacteria

  • Escherichia coli
  • Proteus mirabilis
  • Proteus mirabilis
  • Helicobacter pylori
  • Haemophilus influenzae

Despite the fact that Amoxil is effective against many pathogenic microorganisms, it does have some drawbacks. A weakness of the drug is the lack of activity against staphylococcus infection and some types of gram-negative bacteria.

One of Amoxil advantages is its resistance to acidic conditions of the gastrointestinal juice. This property allows taking the antibiotic orally, while maintaining high bioavailability of the active substance.

Amoxil

Dosage forms

The active ingredient of Amoxil is the antimicrobial drug Amoxicillin, discovered in the 1970s by Beecham scientists. Only oral forms of the antibiotic are available on the pharmaceutical market of the US. Today, you can buy Amoxil as:

Tablets

500 mg

875 mg

Capsules

250 mg

500 mg

Chewable tablets

125 mg

200 mg

250 mg

400 mg

Oral suspension

125mg/5ml

200mg/5ml

250mg/5ml

400mg/5 ml

* In some countries, such as Australia, the UK, the New Zealand, on a par with oral forms, patients can use parenteral form of Amoxil (powder for injection), as well.

Mechanism of action

The mechanism of antimicrobial action of Amoxil is associated with damage to the cell membrane (coating) of the pathogenic bacteria. The antimicrobial drug inhibits the synthesis of the biopolymer murein, which is the main component of the cell wall of the microorganism. Amoxil action leads to the damage and breakage of the bacteria membrane, which leads to its death.

Indications for use

A wide range of antibacterial activity and good tolerability by patients allows using Amoxil to treat infections of varying severity and localization.

Antimicrobial medication can be used by adults and elderly patients. Due to the favorable safety profile, Amoxil can be used for the treatment of infectious diseases in adolescents, infants and neonates.

The list of approved* indications for Amoxil use includes:

Upper respiratory tract infections

  • Sinusitis
  • Tonsillitis
  • Pharyngitis

Bacterial ear infections

  • Otitis media
  • Otitis externa

Urinary tract infections

  • Cystitis
  • Urethritis
  • Pyelonephritis

Skin and skin structure infections

  • Impetigo
  • Cellulitis
  • Erysipelas

Lower respiratory tract infections

  • Community-acquired pneumonia
  • Exacerbations of chronic bronchitis

* Several years ago, the list of indications for Amoxil use included gonorrhea (sexually transmitted disease). If you buy Amoxil today, you will not find gonorrhea in the list of approved indications.

Amoxil can be used as a component of a complex therapy for Helicobacter pylori eradication in patients with duodenal ulcer disease. It is observed that eradication of H. Pylori prevents relapse of the ulcerative disease.

Combined treatment schemes for a bacterial infection with Amoxil may be as follows:

Triple therapy:

  1. Lansoprazole (Prevacid)
  2. Clarithromycin (Biaxin)
  3. Amoxicillin (Amoxil)

Dual therapy:

  1. Lansoprazole (Prevacid)
  2. Amoxicillin (Amoxil)

Amoxil on the international the market

Amoxil is a registered trade mark of British pharmaceutical company GlaxoSmithKline, which was formed in 2000 through the merger of the companies Glaxo Wellcome and SmithKline Beecham.

The right to produce and supply Amoxil in the territory of the US belongs to two companies:

GlaxoSmithKline

Dr. Reddy's Labs

Amoxil suppliers in the international pharmaceutical market are:

Australia

Aspen Pharmacare

UK

GlaxoSmithKline

Canada

Wyeth

New Zeeland

GlaxoSmithKline

If you want to buy Amoxil generics, you can find them on the shelves of pharmacies under the following brand names:

  • Alphamox
  • Amox
  • Cilamox
  • Dispermox
  • Fisamox
  • Ibiamox
  • Lin – Amox
  • Maxamox
  • Wymox
  • Xycilan
  • Moxatag
  • Novamoxin
  • Polymox
  • Ranmoxy
  • Yomax
  • Respillin
  • Rimoxallin
  • Trimox
  • Utimox

Mode of application

Food intake has no effect over the completeness and rate of Amoxil absorption, so the antibiotic can be administered regardless of meals. Oral capsules and tablets should be swallowed whole, without chewing or dividing into parts.

As a rule, adults and adolescents use oral tablets, capsules and chewable tablets to treat infections. The oral suspension is used in patients with impaired swallowing function, babies from 3 months of age and older and children.

Amoxil suspension is supplied in the form of powder, so it should be reconstituted with water before use. The reconstituted suspension should be shaken each time before every consequent use.

For pediatric patients, the suspension can be mixed with baby food or sweetened with not hot beverages (juice). Amoxil suspension can be used within 2 weeks after the reconstitution.

Dosing regimen

If you decide to buy Amoxil online, check out the key information about dosage regimens. The duration of the treatment course depends on the severity of the infection, its localization and rate of clinical symptoms regression. To avoid recurrence of the infection, Amoxil should be continued for 2-3 days after the disappearance of the disease symptoms and signs.

The dosage of Amoxil for the infections of upper respiratory tract, ear, urinary system, skin and soft tissues

Children aged 3 months and older

Mild/Moderate infection:

  • 25 mg per kg of body weight per day, divided into 2 doses
  • 20 mg per kg body weight per day, divided into 3 doses

Severe infections:

  • 45 mg per kg body weight per day, divided into 2 doses
  • 40 mg per kg body weight per day, divided in 2 doses

Adults

Mild/Moderate infection

  • 500 mg twice a day

or

  • 250 mg three times a day

Severe infections:

  • 875 mg twice a day

or

  • 500 mg three times a day
Amoxil dosage for lower respiratory tract infection

Children aged 3 months and older

Mild/Moderate infection:

  • daily dose – 45 mg per kg of weight, divided into 2 doses (every 12 hours)

Severe infections:

  • daily dose – 40 mg per kg of weight, divided into 3 doses (every 8 hours)

Adults

Mild/Moderate infection:

  • 875 mg every 12 hours

Severe infections:

  • 500 mg every 8 hours
Regimens for eradication of Helicobacter pylori infection

Triple therapy

Twice a day:

  • 1 gram Amoxicillin
  • 30 mg Lansoprazole
  • 500 mg Clarithromycin

Dual therapy

Three times a day:

  • 1 gram Amoxicillin
  • 30 mg Lansoprazole

The recommended duration of the treatment course is 14 days. In patients with impaired renal function, Amoxil dose should be adjusted.

  • Depending on the severity of the infection, daily dose of antibiotic in hemodialysis patients can be 250 mg or 500 mg.
  • Patients with severe impaired renal function should not use Amoxil dose of 875 mg.

When used in recommended doses, Amoxil is tolerated well by most patients, and side effects are rare.

Side effects and contraindications

Before the antibiotic Amoxil went on sale, it was evaluated for safety and possible side effects. Allergic reactions, such as urticaria, pruritus, and skin rash, are possible during the use of Amoxil. From the part of the digestive system, taste alteration may manifest, as well as diarrhea, nausea, and pseudomembraneous colitis.

The use of Amoxil can contribute to alteration in the intestinal flora and lead to the growth of Clostridium difficile population, which increases the risk of Clostridium difficile-associated diarrhea. Therefore, the drug should be discontinued when a patient has symptoms of colitis.

Superficial tooth discoloration is possible in children, who take Amoxil suspension and chewable tablets. Prevention of this side effect implies daily/thorough oral care.

Such severe allergic reactions, as vasculitis, angioneurotic oedema, and anaphylaxis, rarely develop and require immediate medical attention.

Amoxil is contraindicated in patients with:

  • individual intolerance to penicillin antibiotics;
  • allergic reactions to Monobactams, Cephalosporins, Carbapenems and other β-lactam antibiotics.

The use of antibiotics during pregnancy is permitted only if the expected benefit to the mother outweighs the potential risk to the fetus.

Amoxil can get into the baby’s body with breast milk and cause diarrhea or fungi infection. For this reason, it is recommended to stop breast-feeding during treatment.

Compliance with the dosing regimen and Amoxil compatibility with other drugs reduces the likelihood of adverse reactions.

Drug interactions

Before you buy Amoxil at a pharmacy or order this antibiotic online, show your pharmacist the list of all medications that you use. Combined use of Amoxil is not recommended with the following drugs:

Methotrexate (immune system suppressant)

Increases methotrexate toxicity.

Probenecid (uricosuric agent)

Increases concentration of Amoxil in the blood.

Macrolides, Tetracyclines, Sulfonamides

Reduces the bactericidal effect of Amoxil.

Allopurinol (antihyperuricemic agent)

Can cause allergic skin reactions.

Amoxil can reduce the contraceptive effect oral estrogen/progesterone contraceptives. In this regard, it is recommended to additionally use other non-hormonal contraception methods for the duration of the antibiotic therapy.

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