Antibiotics: Right Choice for Fighting Bacterial Infeсtions Successfully

Augmentin Online

Augmentin is a combined antimicrobial drug, used for the treatment of infectious diseases in children and adults. Augmentin contains two active components Amoxicillin and Clavulanate.

Augmentin has a bactericidal action and is active against most bacteria and pathogens, which have acquired resistance to the penicillin antibiotics.

  • Augmentin brand belongs to the company GlaxoSmithKline.
  • USsupplier of Augmentin is Dr. Reddy’s Laboratories.

The US pharmacies offer several dosage forms of Augmentin. You can buy Augmentin as:

Powder for oral suspension
  • 125 mg/31.25 mg
  • 200 mg/28.5 mg
  • 250 mg/62.5 mg
  • 400 mg/57 mg
Chewable tablets
  • 125 mg/31.25mg
  • 200 mg/28.5 mg
  • 250 mg/62.5mg
  • 400 mg/57mg
Film-coated tablets
  • 250 mg/125mg
  • 500 mg/125mg
  • 875 mg/125mg
Extended release tablets
  • 1.000 mg/62.5 mg

* Other Augmentin forms are also available at the international pharmaceutical market. For example, in the UK, Augmentin for injection or infusion is available for sale in addition to oral dosage forms.

As a rule, oral Augmentin suspension is typically used for the treatment of infectious diseases in children. This dosage form the most adapted form for use in pediatric patients and allows you to accurately dose the drug taking into account the child’s weight.

Film coated tablets, chewable and extended release tablets are used more often to treat infections in adolescents, adults and elderly patients.

Augmentin

Augmentin in the international market

Due to the favorable safety profile, good tolerability and high therapeutic efficacy, Augmentin remains one of the most popular antibiotics in the world.

Augmentin suppliers  on the international market are the following companies:

UK

Beecham Group

Australia

Aspen Pharmacare

USA

Dr. Reddy ‘s Laboratorie

The drug has been available for sale for more than 30 years and is one of the most frequently prescribed antibiotics. Besides Augmentin, local and online pharmacies offer to buy Augmentin generics, which are known under the brand names:

  • Alphaclav
  • Amclavox
  • Amoclan
  • Pharmaclav
  • Bioclav
  • Amoklavin
  • Co-Amoxiclav
  • Coclavmox
  • Curam duo
  • Moxiclav DUO
  • Clavam
  • Clavulin
  • Moxclav
  • Junoxiclav
  • Deva- Amoxyclav

The mechanism of action of the active components

The mechanism of bactericidal action of Augmentin is associated with the synthesis violation of the microorganism cell wall, which leads to the destruction and death of the bacterium.

The composition of Augmentin includes two active substances:

Amoxicillin (Aminopenicillin)

It can be used as monotherapy for infections, caused by gram-positive and gram-negative microbial flora.

Under the influence of enzymes, which some types of bacteria produce, the antibacterial effect of Amoxicillin may decrease.

Clavulanate Potassium (Beta - lactamase inhibitor)

Inactivates bacterial enzymes, which may decrease the antibacterial effect of Amoxicillin.

Clavulanate extends the range of the antibacterial activity of Amoxicillin and improves the efficiency of treatment of a bacterial infection.

Antimicrobial activity

If you need a broad-spectrum antibacterial agent, you can buy Augmentin. The antimicrobial spectrum of bactericidal action of Augmentin includes the following infectious agents:

Gram-positive bacteria

  • Enterococcus faecalis
  • Streptococcus pyogenes
  • Streptococcus pneumoniae
  • Viridans group Streptococcus
  • Staphylococcus aureus
  • Staphylococcus epidermidis
  • Staphylococcus saprophyticus

Gram-negative bacteria

  • Escherichia coli
  • Klebsiella species
  • Proteus mirabilis
  • Eikenella corrodens
  • Moraxella catarrhalis
  • Enterobacter species
  • Haemophilus influenzae

Augmentin is also effective agaist such anaerobic bacteria, as:

  • Bacteroides spp;
  • Fusobacterium spp;
  • Peptostreptococcus spp.

Indications for use

Wide action range and invulnerability agaist microorganisms that are capable of producing beta-lactamase allows using Augmentin* for the treatment of:

Acute ear infections
  • Otitis media
  • Otitis externa
Urinary tract infections
  • Cystitis
  • Pyelonephritis
Skin and skin structure infections
  • Cellulitis
  • Animal bites
Upper respiratory tract infections
  • Recurrent tonsillitis
  • Acute bacterial sinusitis
Lower respiratory tract infections
  • Exacerbations of chronic bronchitis
  • Community acquired pneumonia

* Due to the ability of affecting pathogenic microorganisms in a bactericidal manner, the range of Augmentin use is wide enough. If you buy Augmentin in Australia or the UK, the list of indications can include the use to treat tooth infections, as well as bone and joint infections (osteomyelitis).

Mode of application

Food does not affect Augmentin absorption. But it is proven that the administration of this antibiotic before a meal contributes to a better drug absorption and reduces the likelihood of gastrointestinal intolerance, as well.

Film coated and extended release Augmentin tablets should be swallow whole, without chewing or biting. It is allowed to wash down the drug with non-carbonated water or juice (excluding grapefruit juice).

It is worth remembering that oral suspension, extended release pills and film-coated tablets are not interchangeable, because they contain different ratio of Amoxicillin – Clavulanate Potassium.

The oral suspension can be replaced with chewable Augmentin tablets, because both forms contain the same ratios of active ingredients.

Augmentin XR is not intended for use in patients with a body weight less than 40 kg. Adults with impaired swallowing function can use the oral suspension.

Augmentin suspension should be prepared immediately before the first use. Drinking water is added into the bottle with the powder, and the contents are shaken well until a homogeneous mass.

The volume of water added depends on the dosage of the suspension, bottle size and in average can amount to:

Augmentin

  • 125 mg/5 ml
  • 67 ml to 134 ml*

Augmentin

  • 250 mg/5 ml
  • 65 ml to 130 ml*

Augmentin

  • 200 mg/5 ml
  • 50 ml to 95 ml*

Augmentin

  • 400 mg/5 ml
  • 50 ml to 90 ml*

* amount of water to prepare the suspension

The prepared suspension should be stored in the fridge for more than 10 days. Before each use, the suspension should be vigorously shaken.

During the period of antibacterial therapy, it is recommended to stop consuming alcohol-containing beverages. Combination of Augmentin with large amounts of alcohol increases the toxic effects over the internal organs, particularly over the liver and kidneys, and increases the likelihood of side effects.

Dosing regimen

If you bought the antibiotic Augmentin and began the treatment, follow the dosing recommendations. Failure to comply with the dosing may slow down the treatment of the bacterial infection.

All therapeutic doses of Augmentin are calculated based on the concentration of its component Amoxicillin. The duration of the treatment and therapeutic dose of Augmentin are selected with the account taken of the patient’s age, the severity of the disease, and the clinical response to treatment.

Depending on the infection severity, the patient’s tolerance and response to treatment, antibiotic can be used:

  • Twice a day
  • Every 12 hours
  • Three times a day
  • Every 8 hours

Doses for children are calculated based on the child’s body weight. It is important to keep in mind that Augmentin  dose should be taken approximately at the same time

Augmentin dosage for neonates and infants under 3 months

For the treatment of infection in neonates and infants under 3 months, it is recommended to use Augmentin suspension 125 mg/5 ml. Dosing regimen in this age group is as follows:

  • Augmentin 30 mg per kg body weight per day;
  • daily dose is divided into two doses 12 hours apart
Treatment of children under 3 months and older with a body weight of up to 40 kg

When selecting the dosing regimen for Augmentin, the severity of the disease plays an important role. Usually, skin infections or chronic tonsillitis require the use of the lowest antibiotic dose.

In acute infectious diseases, bronchitis and pneumonia, Augmentin dose increases. Your doctor may recommend you to buy Augmentin suspension with a high content of active substances. For the treatment of bacterial disease in this age group, patients are prescribed suspension:

  • Augmentin 200 mg and 400 mg (2 times a day);
  • Augmentin 125 mg and 250 mg (3 times a day).
Augmentin dosing options, depending on the child's body weight and the infection severity

To treat mild / moderate infections

  • Augmentin 2 mg/kg – every 12h;

…or…

  • Augmentin 20 mg/kg every 8 hours.

To treat severe infections

  • Augmentin 45 mg/kg – every 12hours;

… or …

  • Augmentin 40 mg/kg – every 8hours.

Adult Augmentin doses are used for the treatment of bacterial infections in children with a body weight of 40 kg and more.

Dosage regimen for adults and children weighing more than 40 kg

To treat mild / moderate infections

  • Augmentin 500mg – every 12 hours;

…or…

  • Augmentin 250 mg – every 8 hours.

To treat severe infections

  • Augmentin 875 mg – every 12 hours;

…or…

  • Augmentin 500 mg – every 8 hours.

Side effects and contraindications

If you have never used Augmentin before, check with your pharmacist for frequent and rare side effects. If you order Augmentin online, you can get a free consultation from the pharmacist of the online pharmacy.

The most frequently manifesting side effects of Augmentin are upset stomach, nausea and vomiting, pain in the stomach. The frequency of diarrhea is marked less. When the antibiotic is taken twice a day, diarrhea occurs less frequently, than it does with triple Augmentin administration.

In some patients, skin rashes and urticaria, vaginal mycosis may appear. In rare cases, cholestatic jaundice and hepatitis are possible, as well as reversible thrombocytopenia, and head pain.

The vast majority of patients tolerate Augmentin well and do not experience discomfort or adverse events.

Augmentin is contraindicated in patients, in whom previous use of antibiotics caused the development of cholestatic jaundice or hepatic dysfunction. The antibiotic is contraindicated in patients with increased sensitivity to penicillins and cephalosporins.

Drug interactions

To avoid side effects, it is not recommended to combine Augmentin with the following medications:

Warfarin, Coumadin

(oral anticoagulants)

Allopurinol

(antihyperuricemic agent)

Probenecid

(uricosuric agent)

Joint use of oral estrogen/progesterone contraceptives wih Augmentin may reduce the effectiveness of birth control pills. To prevent unintended pregnancy during treatment, it is recommended to use additional contraception methods.

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