Antibiotics: Right Choice for Fighting Bacterial Infeсtions Successfully

Bactrim Online

International non-proprietary name
Active ingredients and dosage forms
Indications for use
Posology and Administration

Side effects
Interaction with other medications
Bactrim price online (without prescription)
Bactrim price online (with prescription)
List of Bactrim Generic Brands
Leaflet and booklet downloads
Clinical References and resources

Bactrim is a combined antimicrobial drug that is used to treat a variety of infectious diseases in children and adults. The drug stops the development of bacteria causing the infection, and does not work against diseases that are caused by viruses.

  • Bactrim is a brand of Hoffmann-La Roche Company.
  • The drug is supplied to the US market by the company Sun Pharma.

Since the creation of Bactrim, a large number of new antibiotics appeared on the US pharmaceutical market.

Despite this, Bactrim still remains one of the most effective drugs for the treatment of infectious diseases, caused by bacteria and aerobic microorganisms.

Due to the growing demand for effective and safe antibiotics, a lot of Bactrim generics are available on the international pharmaceutical market.

In the US, you can buy Bactrim generics under the international non-proprietary name "Sulfamethoxazole and Trimethoprim" and under the trade names:

  • Sulfamethoprim
  • Sulfatrim
  • Uroplus
  • Septra
  • Sulmeprim
  • Trimeth/Sulfa

In other countries, branded Bactrim generics are sold under other trade names.

Australia
  • Resprim
  • Septrin
Canada
  • Roubac
  • Protrin
UK
  • Co-Trimoxazole
  • Fectrim

Active ingredients and dosage forms

The antibiotic Bactrim contains two active ingredients:

  • antibacterial sulfonamide Sulfamethoxazole;
  • bacteriostatic antibiotic Trimethoprim.

Separately, these medications are used to treat infectious diseases. However, the combination of Trimethoprim and Sulfamethoxazole has a higher efficiency, than either of these agents alone does.

U. S. doctors usually prescribe Bactrim as oral tablets and suspension to their patients. Bactrim injection solution is used for intravenous infusion and is prescribed very rarely.

Bactrim

The oral tablets Bactrim may contain a usual dose or a doubled dose of the active components. In local and online pharmacies, you can buy:

Bactrim

  • 80 mg Trimethoprim
  • 400 mg Sulfamethoxazole

Bactrim DS

  • 160 mg Trimethoprim
  • 800 mg Sulfamethoxazole

Regardless of the dosage, tablets are supplied in bottles by 100 pieces in each. This antimicrobial medication should be kept in a light-resistant container, dry place at a temperature of 20°C to 25°C (68°F to 77°F).

The oral suspension Bactrim 200 mg/40 mg is being sold in the United States for about 40 years. Usually, it is used to treat uncomplicated infections in patients with impaired swallowing function, and in children aged 2 months and older.

Before each use, Bactrim suspension should be shaken well. The storage temperature for the suspension should not exceed 30°C.

The suspension is packed in amber glass bottles of 50 ml or 100 ml with a child resistant plastic closure. For accurate dosing of the antibiotic, the buyer gets a dosing spoon together with the suspension.

Injection infusion of Bactrim is usually used to treat complicated infections in patients of all age groups (except for infants younger than 2months).

Injections are supplied in 10 ml (single-dose) and 30 ml multiple dose vials, and must be diluted with 5% dextrose solution before use. Your doctor or pharmacist may recommend you to buy Bactrim in vials of different volume, containing different amounts of active ingredients:

10 ml vials

1 ml of Bactrim contains:

  • 16 mg Trimethoprim
  • 80 mg Sulfamethoxazole

30 ml vials

5 ml of Bactrim contains:

  • 80 mg Trimethoprim
  • 400 mg Sulfamethoxazole

Indications for use

Bactrim is approved for use in infants (2 months of age and older), children and adults for the treatment of the following infections:

Urinary tract infections
  • Pyelonephritis
  • Cystitis
  • Urethritis
Respiratory tract infections
  • Acute Exacerbations of Chronic Bronchitis
  • Pneumocystis jiroveci Pneumonia
Gastrointestinal tract infections
  • Shigellosis
  • Traveler’s Diarrhea
  • Typhoid fever
Ear infections
  • Acute otitis media

Posology and Administration

Bactrim tablets and suspension are taken without regard to meals. Intake of the antibiotic after a meal reduces the likelihood of side effects from the part of the gastrointestinal tract.

Bactrim pills should be swallowed whole and washed down with a glass of still water. If  the patient has a difficulty swallowing tablets, better buy oral suspension Bactrim.

The dosing regimen is determined depending on the severity and type of infectious disease.

Bactrim dosage for adults

Option 1: 1 Bactrim DS tablet every 24 hours

Option 2: 2 Bactrim tablets every 12 hours

Duration of treatment for adult patients

Bronchitis UTIs: 10 to 14 days

Shigellosis Traveler’s Diarrhea: 5 days

In some countries, Bactrim has a longer list of indications. In Australia, for example, this antibiotic is prescribed for the treatmentof skin and wound infections, and sepsis.

Therapeutic doses for the treatment of infections in children are calculated based on the child’s body weight.

Bactrim dosage for children

  • 1 ml of Bactrim suspension, per 1 kg body mass, per day.
  • The daily dose is divided into 2 parts and taken every 12 hours.

Duration of treatment for children

  • Urinary traction infections
  • Acute otitis media
  • 10 days

For the treatment of pneumocystis pneumonia (PCP), the same Bactrim dose is used in adults and children. The dose depends on the patient’s weight and Bactrim dosage form.

Dosage of Bactrim suspension
  • Up to 1.25 ml per kg of weight
  • Divide in 1-2 doses
  • Use no more than 3 weeks
Dosage of Bactrim infusion
  • Up to 1.25 ml per kg of weight
  • Divided into 3-4 doses
  • Use no more than 2 weeks

Intravenous Bactrim infusions should be introduced slowly, within 60-90 minutes.

Side effects

See the leaflet for a full list of adverse reactions that were identified during clinical trials and after the start of Bactrim sales.

When used in the recommended dosages, Bactrim is generally well tolerated. The most common adverse reactions are skin rash and gastrointestinal disorders, such as diarrhea, nausea, and abdominal pain.

From the part of bloodmaking organs, the number of leukocytes and neutrophils in the blood may reduce. Most often, these adverse reactions are asymptomatic and disappear after Bactrim discontinuation.

In some patients, the drug can cause shortness of breath and cough, promote frequent urination and accumulation of potassium in the blood. The most serious adverse effects include hypersensitivity reactions, angioedema, and Stevens-Johnson Syndrome.

When the first signs of hypersensitivity reactions appear, Bactrim administration should stop, and the patient should see a doctor and consider alternative treatment for infection.

Interaction with other medications

Bactrim may interact with some drugs through altering their blood concentration and efficiency. At that, patients may suffer from some discomfort and side effects.

Combining Bactrim with the following drugs promotes an increase in their effects:

Anticoagulant agents

  • Warfarin
  • Phenprocoumon

Hypoglycemic agents

  • Repaglinide
  • Rosiglitazone

Cardiovascular agents

  • Digoxin
  • Amiodarone

Antibacterial agents

  • Rifampicin
  • Dapsone

Anti-epileptic drugs

  • Phenytoin

Arrhythmia medications

  • Dofetilide

Combination of Bactrim with medications used for Alzheimer’s Disease, like Memantine, increases the probability of such neurological collateral effects, as myoclonus (sudden muscular spasms) and delirium (consciousness confusion).

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