Levaquin acts as bactericidal agent and has two complex mechanisms of action. Both mechanisms affect the DNA of bacteria and cause their death.
Levaquin is usually prescribed to patients aged 18 years and older. Less commonly, this fluoroquinolone is used to treat patients older than 6 months of age, who were exposed to bacteria that cause plague or inhaled anthrax bacteria.
Levaquin is a highly effective antibacterial agent from the group of fluoroquinolones. Unlike its predecessors (early quinolones), it:
The role of Levaquin continues to widen, encompassing more and more infections of organs, soft tissues, bones and joints.
Approval, safety and key facts
Levaquin is the first Levofloxacin-containing antibiotic, approved by the FDA. Levaquin was approved in late 1996 and went on sale in 1997. Due to the excellent benefit-risk balance, the antibacterial agent had reached blockbuster status within just a few years.
Key facts about Levaquin:
- The name of the active substance – Levofloxacin.
- Manufacturer and Supplier – Janssen Pharms.
- Dosage forms – tablets or solution for injections.
Dosage strength of Levaquin
Besides the brand antibiotic Levaquin, its generic versions are sold in the US, as well. Today, you can buy Levaquin generics in the United States under the generic name Levofloxacin.
Over 15 companies that supply generic Levaquin are registered in the US. Due to competition, induced by generics, sales of the original drug Levaquin slowed down.
Recommended dosing schedule
Levaquin needs to be taken regularly on a daily basis. This allows obtaining a stable antibacterial effect, even if the disease is severe. Despite the fact that Levaquin is used to treat many different bacterial infections, the recommended dosing schedule does not change much.
Single dose and frequency of Levaquin use may be changed, depending on:
- The age of the patient.
- Severity of bacterial infection.
- Functions of internal organs.
- Sensitivity of the suspected pathogen.
Who should not use Levaquin?
Before you begin the treatment, consult a doctor and make sure that the antibiotic is not contraindicated to you. Tell your doctor about any other medicines that you are using, including medicines that you buy without a prescription at a supermarket or pharmacy.
Levaquin should not be used in patients with:
- Tendon rupture associated with the use of quinolones.
- Inflammation or irritation of tendons (tendinitis).
Levaquin is contraindicated in patients with hypersensitivity or allergy to:
Levaquin should not be used during pregnancy or breast-feeding, unless the benefits for the women justifies potential risks to the fetus or child. Due to the risks of serious side effects in infants, careful consideration should be given to stopping antibiotic therapy or stopping breastfeeding.
Drug interactions of Levaquin
Just like any other antibiotic from the group of fluoroquinolones, Levaquin has the potential for interacting with other drugs. This antibiotic may interfere with certain laboratory tests, possibly causing false test results.
Before you buy Levaquin and start the antibacterial therapy, tell your doctor about the use of:
Levaquin may be used with some of them, including if:
- The daily dose does not change.
- The dosage is adjusted.
- Drugs are not taken simultaneously.
Negative results of Levaquin interactions with other drugs may be alternation in the pharmacokinetic properties (absorption, bioavailability, metabolism, excretion, etc.) of one or both drugs, decrease in the effectiveness of the therapy or manifestation of side effects.
Possible adverse reactions of Levaquin
Information about adverse reactions of the body to Levaquin is based on the data, obtained in clinical studies involving over 8000 patients, including children. Some rare reactions, such as tremor, were listed as side effects of Levaquin after the start of sales, based on the results of postmarketing surveillance.
During the antibacterial therapy with Levaquin, frequent side effects are possible, most of which are mild or moderate. Examples are:
- Abdominal discomfort
Most people, who bought Levaquin tablets or solution and take the recommended dose of this antibiotic, do not experience any serious side effects.
Children are more susceptible to gastrointestinal side effects (diarrhea and vomiting), than adults are. Prolonged use of antibiotics increases the risks of musculoskeletal disorders in children and adolescents.
Such reactions may be a symptom of an acute overdose of Levaquin.
A full list of side effects that were identified during the clinical trials and after the start of sales of the antibiotic Levaquin, are available in the package insert.