Antibiotics: Right Choice for Fighting Bacterial Infeсtions Successfully

Lincosamides

Lincosamides are a group of antibiotics used to treat a wide range of bacterial infections of different parts of the body and organs. Lincosamides suppress the ability of bacteria to multiply and thus provide a pronounced antibacterial effect. High doses of antibiotics of the lincosamides group have a bactericidal effect.

The main antibiotics of the lincosamides class are:

  • Lincomycin;
  • Clindamycin.

Lincomycin is available commercially under the brand Lincocin or under its international non-proprietary name “Lincomycin”. While Clindamycin can be bought under a variety of brand names, including:

  • Cleocin
  • Evoclin
  • Clinac
  • Dalacin
  • Clindesse
  • Clinda-T
  • Clindets
  • Clinda-Derm
  • Clindagel

Lincosamides are active against a large number of pathogenic bacteria, such as:

  • Propionibacterim acnes
  • Corynebacterium diphtheriae
  • Clostridium (tetani/perfringens)
  • Staphylococcus aureus
  • Peptostreptococcus anaerobius
  • Fusobacterium (nucleatum/necrophorum)
  • Prevotella melaninogenica
  • Viridans group streptococci
  • Streptococcus (pyogenes/pneumoniae)

Lincosamides are prescription antibiotics. They are not addictive and do not work against viral infections. Before starting treatment, consult your doctor and make sure that this class of antibiotics is right for you.

Lincosamides well penetrate into the body tissues and can be prescribed for the treatment of:

Respiratory tract infections

Bronchitis, otitis, pharyngitis, pneumonia, scarlet fever, sinusitis, tonsillitis.

Skin structure infections

Acne, abscesses, cellulitis, cutaneous gangrene, erysipelas, furuncles, impetigo, lymphadenitis, mastitis, paronychia, wound infections.

Joint and bone infections

Osteomyelitis, septic arthritis

Blood and heart infections

Endocarditis, septicemia

Intestinal infections

Bacillary dysentery

Vaginal infections

Bacterial vaginosis

Lincosamides came into the market in the 60s of the last century and quickly proved to be effective and safe antibacterial agents. Effectiveness of infections treatment depends on many factors, including the choice of the lincosamides subclass and its dosage forms.

You can use different dosage forms of lincosamides that have different pharmacokinetic and pharmacodynamic properties. Depending on the severity and etiology of bacterial infection, lincosamides can be administered in the form of:

  1. gel
  2. cream
  3. capsules
  4. solution
  5. injectable
  6. aerosol (foam)
  7. suppository
  • Lincomycin is usually used for injection or oral administration.
  • Clindamycin can be used for oral, topical, vaginal or injection administration.

Lincomycin is the first antibiotic of the lincosamides class. It is similar to antibiotics of the macrolides group by its structure, mechanism of action and spectrum of antibacterial activity.

Antibacterial activity of Clindamycin exceeds Lincomycin activity. Therefore, it is prescribed for the treatment of infectious diseases more often than Lincomycin.

Amebiasis
Tetracyclines

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