Penicillins are antimicrobial drugs that have a bactericidal effect and used to treat bacterial infections in adults and children.
Penicillins disrupt the synthesis of components of the bacterial cell wall that leads to its death. This group of antibiotics has very low toxicity and is usually well tolerated by patients of any age.
Penicillins are some of the most important groups of antibiotics and include the following types of antibacterial agents:
Aminopenicillins are mainly used to treat uncomplicated tonsillitis, bronchitis, and community-acquired pneumonia. Aminopenicillins can also be a part of complex therapy in the eradication of Helicobacter pylori. These drugs are resistant to gastric acid and can be used orally.
Antipseudomonal penicillins can be used to treat appendicitis complicated by rupture or abscess, peritonitis and other intra-abdominal infections. They are administered parenterally.
Penicillin + Beta-lactamase inhibitor
These drugs are used for the treatment of resistant bacterial infections, including furunculosis, impetigo, and cellulitis. These drugs can be administered either orally or parenterally.
Penicillin G Benzathine
Penicillin V Potassium
- V-Cillin k
- Uticillin VK
- Pfizerpen VK
- Pen-Vee K
- Ledercillin VK
Penicillin G Procaine
- Bicillin C-R
- Duracillin A.S.
Natural penicillins are most often used for the treatment of severe pneumonia, empyema, bacteremia, pericarditis, meningitis, and brain abscess. These antibiotics are destroyed in the acidic environment of the stomach, so they are usually administered parenterally.
Penicillinase resistant penicillins
These drugs are used for the treatment of resistant staphylococcal infections of the urinary tract (pyelonephritis, cystitis), postoperative infections, and infected burns. The main route of administration is parenteral.
Depending on the type of antibacterial agent, penicillins show a high antibacterial activity against the following pathogenic microorganisms:
Penicillins also act on such pathogenic microorganisms as Enterobacter species, Treponema pallidum, and Treponema carateum.
Due to a wide range of antibacterial action, Penicillins are some of the most used antimicrobial medicines today. They are used to treat infections of the:
- genitourinary tract;
- ear, nose, and throat;
- lower respiratory tract;
- skin and skin structure;
- central nervous system;
- abdominal cavity and its lining.
Various dosage forms and dosage strengths of antibacterial drugs allow to select the therapy scheme individually for each patient, taking into account the age, the infection severity and the type of causative agent of the disease.