Antibiotics: Right Choice for Fighting Bacterial Infeсtions Successfully

Zithromax Online

Zithromax dosage forms
Zithromax in pharmacies

Indications for use
Dosing regimen for Zithromax

Side Effects and Contraindications
Drug Interactions
History of creation
Zithromax price online (without prescription)
Zithromax price online (with prescription)
List of Zithromax Generic Brands
Leaflet and booklet downloads
Clinical References and resources

Zithromax is one of most frequently prescribed medicines for the treatment of bacterial infections. The active substance of Zithromax drug is a bacteriostatic macrolide antibiotic with a wide spectrum of action, Azithromycin.

Zithromax has a high activity against:

  • Gram-positive bacteria (incl. Streptococcus pneumoniae and pyogenes, Staphylococcus aureus);
  • Gram-negative bacteria (incl. Haemophilus influenzae and parainfluenzae).

One of the most important properties of the drug is its highly activity against sexually transmitted intracellular pathogens and infectious agents – Chlamydia trachomatis and Neisseria gonorrhoeae.

The drug provides a potent antimicrobial action and has anti-inflammatory and immunomodulatory properties, as well.

If you are looking for a reliable, effective and safe antibiotic, you can buy Zithromax. Oral Zithromax differs favorably from other antibiotics through the fact that:

It has a low potential for adverse drug interactions.

It shows resistance to hydrochloric acid, produced by the stomach.

The antibiotic Zithromax has a long half-life (on average about 68 hours) and high bioavailability, which promotes the accumulation in of the antibiotic in the tissues of internal organs.

Due to the possibility of accumulation in the tissues and creation of high intracellular concentrations, Zithromax  may exhibit a pronounced bactericidal effect in certain conditions.

Zithromax

Zithromax dosage forms

One of several Zithromax forms can be used for the treatment of bacterial infections in children and adults. In local and online pharmacies, patients can buy Zithromax in the following dosage forms:

Oral capsules

250 mg

Oral tablets

250 mg

500 mg

600 mg

Oral suspension

100 mg/5 mL

200 mg/5 mL

Intravenous injection

500 mg

  • Zithromax oral suspension is intended for the treatment of pediatric  patients and patients with impaired swallowing function.
  • Tablets and capsules are prescribed to adults, including the elderly, for the treatment of mild to moderate bacterial infections.
  • Zithromax for injection is used for the treatment of severe pelvic inflammatory disease and pneumonia in adults.

Zithromax in pharmacies

The drug is supplied on the market of the US, Canada, Australia and Western Europe by Pfizer and its subsidiaries. Zithromax manufacturer for the countries of the Western Europe are the Spanish pharmaceutical company Farmasierra Manufacturing (Madrid) and Italy Haupt Pharma Latina. In 2008, the pharmaceutical company Wockhardt has acquired the right to supply Zithromax to the US.

The following companies are indicated as US sub-distributors of Zithromax:

  • Remedy Repack
  • Cardinal Health
  • A-S Medication Solutions
  • Physicians Total Care

If the Zithromax cost seems high to you, you can purchase its generic versions. Generic antibiotics based on the active substance Azithromycin provide the same effect as Zithromax does, yet these can cost less.

Zithromax generics are available under the international non-proprietary name Azithromycin. Besides, patients may buy Zithromax generics under the following trade names:

UK
  • Clamelle
  • Zedbac
Australia
  • Zedd
  • Azith
  • Zitrocin
USA
  • Zmax

Indications for use

To adult patients, Zithromax is prescribed for the treatment of:

  • urethritis and cervicitis;
  • acute bacterial sinusitis;
  • community-acquired pneumonia;
  • sexually transmitted diseases;
  • exacerbations of chronic bronchitis;
  • genital ulcer disease / chancroid (in men);
  • uncomplicated infections of the skin and soft tissues.

The indications for Zithromax use in pediatric patients aged 6 months and older are pneumonia and acute otitis media. This antibiotic can be used as a second-line treatment for pharyngitis and tonsillitis in children aged 2 years and older.

Dosing regimen for Zithromax

Dose and frequency of Zithromax administration are determined individually, with the account taken of the patient’s age and the infection severity. The doctor will tell you where to buy Zithromax, how to use this antibacterial agent and how many doses to take every day.

It is recommended to take the antibiotic one hour before meals or 2 hours after the meals. The daily dose of Zithromax for children is calculated based on the child’s body weight. Depending on the severity of the disease, the dosing regimen can be as follows:

Dose for acute tonsillitis or pharyngitis

  • 12 mg of Zithromax per kg body weight, once a day.
  • Duration of the course is 5 days.

Dose for acute bacterial sinusitis

  • 10 mg of Zithromax  per kg body weight per day.
  • Duration of the course is 3 days.

Three dosing regimens for Zithromax are available for the treatment of acute otitis media:

One-day therapy

A single dose of 30 mg per kg of body weight once a day.

Three-day therapy

10 mg of Zithromax per kg of body weight, once a day.

Five -day therapy

On the first day – 10 mg per kg of body weight. Starting from the second day – 5 mg per kg body weight, per day.

Zithromax dosage for pneumonia:

  • 1 day of treatment: 10 mg per kg of body weight per day.
  • From day 2 to day 5 of treatment: 5 mg per kg of body weight, every 24 hours.

Dosage regimen for Zithromax in:

  • Acute bacterial sinusitis: 500 mg Zithromax dose, once a day, for 3 days.
  • Cervicitis and urethritis: 2 grams Zithromax dose, once.
  • Chancroid: 1 gram Zithromax dose, once.

For the treatment of uncomplicated infections of skin and skin structure, community-acquired pneumonia, tonsillitis and pharyngitis, adults are prescribed:

  • In the 1 st day – 500 mg of Zithromax, once a day;
  • Starting from Day 2 to Day 5 (inclusive) – 250 mg of Zithromax, once every 24 hours.

The dosage regimen for treating chronic obstructive pulmonary disease depends on the severity of the disease. The course of treatment can last 3 or 5 days.

Three-day therapy

  • 500 mg Zithromax dose, once a day.

Five-day therapy

  • On the first day – 500 mg, once every24 h;
  • On day 2 to day 5 – 250 mg, once every 24 h.

To ensure that the antibiotic therapy goes in the most effective and comfortable manner, the antibiotic doses should be taken at about the same time of the day. If you run out of stock, buy  Zithromax beforehand so that you do not miss the next dose.

The pharmacokinetic characteristics of the drug allow taking Zithromax once a day and adjust the duration of treatment. The peak of antibiotic concentration usually comes in 24-48 hours after the first dose. During the treatment course, it is recommended to give up alcohol consumption.

Side Effects and Contraindications

When used in recommended dosages, Zithromax is well tolerated by patients of all age groups. Most side effects are mild, yet they can cause certain discomfort to the patient.

The most frequently reported adverse reactions during the treatment course manifest from the part of the gastrointestinal tract, including nausea, diarrhea, and abdominal pain. These effects can manifest in both adults and children.

Occasionally, patients may have allergic skin reactions, headaches, and pain in the chest. Vaginitis and anorexia are possible in women taking Zithromax.

To reduce the probability of adverse effects, it is important to comply with the recommended dosing regimen and take Zithromax in time.

Contraindication to the drug use is:

  • severe liver and kidneys disorders;
  • individual hypersensitivity to macrolides or ketolide antibiotics.

The use of the antibiotic during pregnancy or lactation period is justified only when the intended benefits to the mother outweigh the potential risk to the fetus or baby.

Drug Interactions

Before Zithromax appeared on sale, it was evaluated for safety. Zithromax has a low potential for drug-drug interactions. It was clinically proven that this medication used in the recommended dosages does not interact with:

  • Triazolam (hypnotic drug);
  • Fluconazole (antifungal medication);
  • Carbamazepine (epilepsy medication);
  • Didanosine (medication used to treat HIV/AIDS);
  • Theophylline (medication used to treat asthma and other lung diseases).

Caution is recommend for simultaneous use of Zithromax with:

Terfenadine (antihistamine)
Digoxin (cardiac glycoside)
Ergotamine (ergot alkaloid)
Cyclosporine (Immunosuppressant)

Zithromax passed a number of clinical trials, which have proven high efficacy and a favorable safety profile for patients of different age groups.

Even today, Zithromax continues being a unique drug in most countries of the world that allows to effectively fight with a variety of infectious diseases.

History of creation

History of the creation and use of this drug has over 35 years and started with the fact that the Croatian pharmaceutical company Pliva announced the development of a totally new antibiotic called Azithromycin in the late 1970s.

In 1981, Pliva filed a patent application for their invention, and registers their rights for the antibiotic around the world, including the USA. Some time later, the US group Pfizer became interested in the development of Pliva and offered her services to promote marketing of the drug.

In 1986, the two companies have signed a license agreement for the transfer to Pfizer of the rights for supply and sale of Zithromax on the market of the USA, Western Europe, Australia and other countries. Pliva has reserved the right to sell the antibiotic in the territory of the Eastern and Central Europe.

In 2000, Pfizer initiated an extensive advertising campaign to promote branded version of Azithromycin – Zithromax in the US. Soon, the antibiotic got on the top positions of the antibacterial drugs market and was sold in almost all countries of the world.

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